Buy Premarin (Estrogen)
Online without Prescription.
No prescription Needed.
Free worldwide Shipping Fee.
name : Premarin
Name : Estrogen
: Female Hormones : Oestrogens & Progesterones & Related
FDA Pregnant Category : Not established
What is it used for?
- Symptoms of the menopause
- Used to help prevent the development of osteoporosis
How does it work?
Oestrogen is the main sex hormone in the female body. Certain parts of the body such as the vagina, bones and breasts rely on oestrogen to function normally. When the levels of oestrogen are low, these tissues can slowly degenerate. In addition low levels of oestrogen can cause distressing symptoms such as hot flushes, mood swings and vaginal dryness.
Oestrogen may be supplemented to help reduce
distressing symptoms of menopause and for the long-term prevention
of bone loss (osteoporosis) that may occur in the years after
menopause. This is known as hormone replacement therapy (HRT).
It is essential that women with an intact womb
be given a progestogen (which acts like another another female
sex hormone called progesterone), in combination with oestrogen.
This is to prevent overstimulation of the lining of the womb (endometrium),
which may otherwise occur with the use of oestrogen. Certain HRT
medicines contain both hormones. Premarin contains only oestrogen,
therefore it should be used only by women who have had their womb
removed surgically (hysterectomy), or in conjunction with a progestogen.
How should Premarin (Estrogen)
Premarin comes as a tablet to take by mouth,
patches to apply externally to the skin, and as a cream to be
inserted into the vagina. Oral Premarin usually is taken by mouth
either every day or on a cyclical basis: once a day for 21 days
and then none for 7 days; then the cycle is repeated. However,
for treating cancer it usually is taken three times a day, every
day for at least 3 months.
Skin patches usually are applied either once
or twice weekly for three weeks (on the same days each week),
followed by 1 week without the drug (patch); then the cycle is
repeated. The package is designed to help you remember when to
apply fresh skin patches.
To apply a skin patch, follow the directions provided and these
-- Remove the skin patch from its protective
pouch and peel off the protective strip, exposing the adhesive
-- Place the adhesive side against a clean,
dry, and not excessively hairy area of skin on the trunk of your
body, preferably your abdomen (not your waistline or breasts,
since tight clothing may rub the patch). Do not apply the patch
to oily, broken, or irritated skin.
-- Press the patch on the selected site firmly
with the palm of your hand for about 10 seconds, making sure that
the edges adhere to your skin. If the patch accidentally comes
off, you can either reapply it or apply a fresh patch, but follow
your regular dosing schedule.
Remove and discard the patch and apply a fresh patch according
to the schedule prescribed by your doctor. To prevent skin irritation,
use a different site for each application and wait at least 1
week before using a particular area again. Used patches should
be cut up and disposed in a manner out of reach of children and
To use the vaginal cream, your doctor will set
up a dosage schedule for you. If you are to use it once a day,
it is best to use it at bedtime. Follow the directions that come
with the vaginal cream and these steps:
-- Fill the special applicator that comes with
the cream to the level indicated.
-- Lie on your back with your knees drawn upward and spread apart.
-- Gently insert the applicator into the vagina; then push the
plunger to release the medication.
-- Withdraw the applicator.
-- Discard the applicator if it is disposable. If the applicator
is reusable, pull it apart and clean it with soap and warm water
after each use.
-- Wash your hands promptly.
Ask your pharmacist or doctor any questions you
have about using the vaginal cream. You may wish to wear a sanitary
napkin after inserting the cream to keep your clothes clean.
Follow the directions on your prescription label
carefully, and ask your doctor or pharmacist to explain any part
you do not understand. Take Premarin exactly as directed. Do not
take more or less of it or take it more often than prescribed
by your doctor. Do not stop taking Premarin without talking to
Ask your pharmacist or doctor for a copy of the
manufacturer's information for the patient
- In women with an intact uterus, long-term use
of oestrogen therapy will require the addition of a progestogen
to prevent the risk of over-growth (hyperplasia) and possible
cancer of the lining of the womb (endometrium).
- It is important to be aware that all women
taking HRT appear to have a small increase in the risk of being
diagnosed with breast cancer, compared with women who do not take
HRT. However, this risk must be weighed against the benefits of
taking HRT, such as prevention of osteoporosis. You should discuss
the risks and benefits of HRT with your doctor before starting
treatment. Women on HRT are advised to have regular breast examinations
and mammograms, and to practice breast self-examination.
- It is important to be aware that women taking
HRT have a slight increase in the risk of abnormal blood clot
formation (deep vein thrombosis and pulmonary embolism) compared
with women not taking HRT. The Committee for the Safety of Medicines
believes that the overall benefits of HRT outweigh the risks involved,
but that those with a personal or family history of thrombosis
or other risk factors (eg smokers, obesity, recent surgery, immobility)
should carefully discuss this with their doctor.
- A woman is considered fertile for two years
after her last menstrual period if she is under 50, or for one
year if over 50. HRT does not provide contraception for women
who fall within this group. If a potentially fertile women is
taking HRT but also requires contraception, a non-hormonal method
(eg condoms) should be used.
- Regular gynaecological tests are recommended
for women taking this medicine.
- Notify your doctor if you develop migraine-like
headaches, yellowing of the skin or eyes (jaundice) or any visual
- HRT may affect the results of some hormone
or liver function tests.
- There has been a reported increase in the
risk of surgically confirmed gall bladder disease in postmenopausal
women receiving oestrogen treatment.-
Use with caution in
- Decreased kidney function
- Disorder causing deafness in adult life (otosclerosis)
- Fibroids of the uterus
- Heart disease
- High blood pressure (hypertension)
- History of heart attack
- History of stroke
- Life long inherited blood diseases which can cause a variety
of symptoms, including mental health problems (porphyrias)
- Long-term inflammation of skin and some internal organs (systemic
- Malignant skin cancer (melanoma)
- Multiple sclerosis
- Treatment of migraine
Not to be used in
- Breast cancer or history of breast cancer
- Cancer that is responsive to female hormones (oestrogen dependent
neoplasia) eg endometrial cancer
- Current or previous blood clot in the blood vessels (thromboembolism)
- Disorders that increase the risk of blood
clots in the blood vessels (thromboembolic disorders)
- Liver disease
- Severe cardiovascular disease
- Severe kidney disease
- Vaginal bleeding of unknown cause
This medicine should not be used if you are allergic
to one or any of its ingredients. Please inform your doctor or
pharmacist if you have previously experienced such an allergy.
If you feel you have experienced an allergic
reaction, stop using this medicine and inform your doctor or pharmacist
Pregnancy and Breastfeeding
Certain medicines should not be used during pregnancy
or breastfeeding. However, other medicines may be safely used
in pregnancy or breastfeeding providing the benefits to the mother
outweigh the risks to the unborn baby.Always inform your doctor
if you are pregnant or planning a pregnancy, before using any
- This medicine should not be used in pregnancy.
Seek medical advice from your doctor.
- This medicine should not be used by breastfeeding mothers. Discuss
this with your doctor.
Medicines and their possible side effects can
affect individual people in different ways. The following are
some of the side effects that are known to be associated with
this medicine. Because a side effect is stated here, it does not
mean that all people using this medicine will experience that
or any side effect.
- Changes in mood
- Breast tenderness/swelling
- High blood calcium level (hypercalcaemia)
- Leg cramps
- Excessive fluid retention in the body tissues, resulting in
- Changes in sex drive
- Intolerance to contact lenses
- Gastrointestinal disturbances including bloating, cramps, nausea
The side effects listed above may not include
all of the side effects reported by the drug's manufacturer.
For more information about any other possible
risks associated with this medicine, please read the information
provided with the medicine or consult your doctor or pharmacist.
How can this medicine affect other
Most interactions have been demonstrated with
the oral contraceptive pill (also containing oestrogens), and
not specifically for the oestrogens used in hormone replacement
dosages. Some of the following are therefore only theoretical
interactions rather than proven effects.
Medicines that increase the elimination, lower
blood levels or reduce the therapeutic effect of oestrogens:
-Antibiotics (e.g. rifampicin, rifabutin)
-Antiepileptics (e.g. carbamazepine, phenobarbitol, phenytoin,
-Antifungals (e.g griseofulvin)
-Antivirals (e.g. ritonavir, nelfinavir, nevirapine and possibly
Medicines that may have their effects or blood
levels increased by oestrogens:
-Corticosteroids - blood levels may be increased
-Ciclosporin (cyclosporin) - blood levels may be increased
-Ropinirole - blood levels may be increased
-Theophylline - blood levels may be increased
Medicines that have their effects reduced by oestrogens:
Your doctor will start therapy with this medication
at a low dose. He or she will want to check you periodically at
3- to 6-month intervals to determine the need for continued therapy.
Hot Flashes Associated with Menopause
The usual dosage is 0.3 to 1.25 milligrams daily.
If you are still having periods, the doctor will start the Premarin
on the fifth day of your cycle, have you take it for 3 weeks,
then give you 1 week off.
Tissue Degeneration in the Vagina
The usual dosage is 0.3 to 1.25 milligrams or more daily. The
drug is taken cyclically (3 weeks on and 1 week off).
Low Estrogen Levels Due to Reduced Ovary Function
The usual dosage is 2.5 to 7.5 milligrams daily,
taken in several small doses, for 20 days, followed by a 10-day
rest period. If you do not have your period by the end of this
time, the same dosage schedule is repeated.
If you start to bleed before the end of the 10-day
period your doctor will start you on another 20-day cycle, with
an oral progestin added during the last 5 days. If you start to
bleed before the second cycle is over, stop taking the medication
and tell your doctor.
Ovary Removal or Ovarian Failure
The usual dosage is 1.25 milligrams daily, cyclically
(3 weeks on and 1 week off). Your doctor will adjust the dosage
according to the severity of your symptoms and your response to
Prevention of Osteoporosis (Loss of Bone Mass)
The usual dosage is 0.625 milligram daily, taken
cyclically (3 weeks on and 1 week off).
Advanced Androgen-Dependent Cancer of the Prostate,
for Relief of Symptoms Only
The usual dosage is 1.25 to 2.5 milligrams 3 times daily.
Breast Cancer (for Relief of Symptoms Only) in
Appropriately Selected Women and Men with Metastatic Disease
The suggested dosage is 10 milligrams 3 times
daily for a period of at least 3 months. Tell your doctor if you
have any unusual bleeding.
PREMARIN VAGINAL CREAM
Given cyclically for short-term use only.
Degeneration of Genital Tissue or Severe Itching in the Genital
The recommended dosage is one-half to 2 grams
daily, inserted into the vagina, depending on the severity of
the condition. You will use the cream for 3 weeks, then stop for
1 week. Tell your doctor if you notice any unusual bleeding.
Follow a 28-day cycle. Take 1 maroon Premarin
tablet every day for the first 14 days; on the 15th day, begin
taking 1 light-blue tablet daily.
The usual starting dose is one 0.625-milligram/2.5-milligram
tablet once a day. If this dose proves insufficient, your doctor
may increase the dose to one 0.625-milligram/5-milligram tablet
once a day.
The usual starting dose is 0.625 milligrams a
day. If this proves insufficient, the doctor may gradually increase
the dose up to a maximum of 1.25 milligrams daily.
Numerous reports of ingestion of large doses
of estrogen-containing oral contraceptives by young children indicate
that acute serious ill effects have not been observed. Overdosage
of estrogens may cause nausea, and withdrawal bleeding may occur
When you miss a dose
Take the forgotten dose as soon as you remember.
If it is almost time for the next dose, skip the one you missed
and go back to your regular schedule. Never try to "catch
up" by doubling the dose.
Store at room temperature (approximately 25 C).
Our Most Popular Drugs
Antihistamine,Antiallergy,Minor Ranquillizer ,
Antiviral, Antifungals, Antiinfectives
Buy Premarin (Estrogen)
Online without Prescription.
No prescription Needed.
Free worldwide Shipping Fee.